HOW IT WORKS…

FAQs

Doctors state that 80% of heart attacks and strokes can be prevented – but this is achievable from making a range of changes – not just one.

One of the key factors that contribute to heart attack or stroke is the problem of ‘sticky blood’ or ‘platelet aggregation’. Fruitflow® helps keep the blood flowing smoothly to help maintain a healthy heart and cardiovascular system.

Fruitflow® is unique, and works alongside cholesterol lowering products to help keep people to do that bit more to look after their hearts. The science behind Fruitflow® has been published in the authoritative American Journal of Clinical Nutrition (AJCN). The AJCN is internationally recognised as the highest-ranked peer-reviewed journal in the nutrition field.

No. The extract we take from ripe tomatoes is natural, and not changed from its natural form. It is not bio-engineered or genetically modified.  The active ingredient is in the liquid around the seeds of tomatoes.  We isolate that element and then concentrate it.

By doing this we maximise the bio-availability and also the health benefit.

Yes, it would be perfectly acceptable as part of a healthy, balanced diet that is low in fat, low in sugar and salt with plenty of fruit and vegetables and meals based on starchy carbohydrates e.g., bread, potatoes, cereals, pasta, rice, yam.

It is true to say that diabetics are more prone to activated or ‘spiky’ platelets which can lead to increased platelet aggregation, and people whose platelets are in an undesirably activated state could benefit from taking Fruitflow® daily to help keep their platelets smooth.   We suggest you speak to your own GP, dietician or diabetic clinic if you would like more advice.

Fruitflow® has not been studied in pregnant women. However, there is no evidence that Fruitflow® would be harmful during pregnancy, given that all the ingredients are widely consumed in the normal UK diet.

Pregnant women or those breast-feeding should seek their doctor’s advice before taking Fruitflow®.

Deep vein thrombosis or DVT is caused by a blood clot in the circulatory system. This can arise due to imbalances in clotting factors in the blood, and is more likely for people whose blood is flowing slowly – such as people who sit down or lie down all day, pregnant women, and people whose lower leg veins are in poor condition.

Fruitflow + Omega-3 contains natural compounds which can help maintain healthy blood flow, and have been shown in studies to affect part of the mechanism by which DVT arises (specifically, to affect tissue factor, a pro-coagulant which is linked to thrombosis). Further work is being undertaken to examine this further.

Some experts suggest that everyone over the age of 50 could benefit from a reduction in platelet function. Many people in this age group – in particular, people with high cholesterol levels, who are overweight or who smoke – are reported to have abnormally ‘sticky’ platelets. This is also true for diabetics in all age groups. People whose platelets are in an undesirably activated state could benefit from taking Fruitflow® daily to help keep their platelets smooth and their blood flowing smoothly.

In our largest single study, positive effects were observed in 97% of individuals tested. This compares favourably with single-drug therapies, such as Aspirin, which can be ineffective in up to 30% of individuals.

Fruitflow® works by preventing blood platelets from clumping together inside the body.  In our blood there are disk shaped platelets, which we need for normal blood clotting when we cut ourselves.  However, under certain conditions (e.g. an unhealthy diet) they can become irritated or ‘spiky’ inside the body, making them more likely to clump together and form an internal clot – which can be harmful.  Fruitflow® ‘smoothes’ these platelets, therefore benefiting circulation, and helping maintain a healthy heart and cardiovascular system.  So, it does not reduce blood pressure, which is related to the structure of the arteries, but it does work to keep blood flowing smoothly through the body.

The Omega-3 used in Fruitflow®+ Omega-3 is DSM’s MEG-3™ which is naturally sourced from purified fish oils, concentrated and encapsulated to lock in the benefits of Omega-3 EPA/DHA while locking out any taste or smell – see www.meg-3.com for full details.

If you do have a known allergy to fish, we would not recommend taking Fruitflow® + Omega-3, and we would suggest that you consult further with your GP.

If you are taking anticoagulant medication, such as a daily dose of Warfarin, then you should seek your doctor’s advice as to what is most appropriate for you.

If you do have a known allergy to tomatoes, we would not recommend taking Fruitflow®. The extract is derived from tomatoes. Although it contains no proteins from the tomato, which tend to be the allergens, we suggest you consult your GP before consuming Fruitflow®.

Many factors interact to produce high risk of cardiovascular disease; these include: age (risk increases with increasing age), prior family history of cardiovascular disease, cholesterol level (risk increases with higher cholesterol), tobacco usage, diabetes, ethnic origin, stress, diet and exercise. The highest risk is associated with advanced age, high cholesterol, smoking and diabetes.

If you would like more information on cardiovascular disease risk, contact your GP who can estimate your individual risk and provide advice.

Yes. Fruitflow® works differently from cholesterol lowering products as it works directly on blood platelets. These types of product may complement each other, and can be combined as part of a healthy diet and lifestyle.

No. It has been shown that Fruitflow® components work specifically on blood platelets and do not disrupt the whole blood clotting process – even at high dosages. Also the amount of Fruitflow® has been carefully chosen to ensure that effects on platelets can be reversed if adverse conditions arise – for example if there is a sudden injury to tissue.

This means that blood clotting on injury will occur as normal after taking Fruitflow®, and excess bleeding is not a problem.

The recommended dose of one capsule each day contains the right amount of Fruitflow®, the active tomato extract, to be effective. The benefits will not increase with increased consumption. However, there is no evidence that taking more than the recommended dose of Fruitflow® would be in any way harmful.

Compared to other dietary antiplatelet extracts, for example aged garlic extract or cocoa extracts, Fruitflow® has a broader scope and is likely to be effective in more people. This is because other natural antiplatelet extracts generally contain one kind of bioactive compound only. Fruitflow®, however contains a much broader range of components, all derived from the tomato, which combine to produce a range of different effects on platelets.

As Fruitflow® is intended for maintenance of heart health rather than treatment of heart disease, it has been designed to reduce platelet aggregation less aggressively than antiplatelet drugs such as aspirin.  Aspirin will result in total and irreversible inhibition of platelet aggregation – which is why bleeding complications can sometimes occur.

Fruitflow® contains sufficient bioactive tomato components to give a significant reduction in platelet function; although less than 100%, this level of platelet inhibition is a safer and more acceptable outcome from a natural health supplement.

However, Fruitflow® is not a drug, nor has it been developed to replace drugs for patients who need them.   It has been developed for healthy adults who understand the dangers of cardiovascular disease, and want to take control of their diet and lifestyle to maintain cardiovascular health.  If you are taking anticoagulant medication, such as a daily dose of Aspirin, then you should seek your doctor’s advice as to what is most appropriate for you

Provexis have conducted a clinical trial that compares the effectiveness of Fruitflow® with Aspirin.

It found that Fruitflow® slows the reactions of platelets down but still lets them clot normally, while daily Aspirin brings them close to a complete halt so that they clot much more slowly. This means that Fruitflow® is suitable to reduce platelet hyperactivity in normal people. Aspirin maybe necessary for those at really high risk but is unsafe in normal people. The difference arises because although Fruitflow® and Aspirin share several points of action, they also diverge: Aspirin in an irreversible manner, Fruitflow® in a reversible manner.

This study was submitted to the European Journal of Clinical Nutrition (EJCN) in February 2016.

In some people, long-term use of Aspirin can result in gastric bleeding. Fruitflow® is not known to have any such effect.

Long-term studies of the effects of Fruitflow® usage in the general population will be needed to obtain a body of data which can be analysed to show whether Fruitflow® consumption is linked to a reduction in risk or incidence of heart attack and stroke.

However other dietary antiplatelet agents such as fish oil, which has similar effects on platelet function to Fruitflow®, have been shown to be associated with reduction in CVD-related events in some studies. Similar findings could be expected for Fruitflow®.

Giving antiplatelet drugs is a proven method of reducing risk of cardiovascular events and improving heart health, supported by a large number of trials from all around the world. Evidence also exists to show that antiplatelet drugs slow the development of fatty plaques in the blood vessels, which is one of the main causes of cardiovascular disease.

Platelets from some individuals at high risk of dying from a cardiovascular disease-related event – such as diabetics, or people who have had a previous stroke – are in a more activated or spiky state than those from low risk populations – such as people consuming a Mediterranean diet. Control of platelet function is known to be an effective therapy in these high-risk groups.

There are no side effects from taking Fruitflow®.

Although both Fruitflow® and lycopene are derived from tomatoes, they work in different ways.

Fruitflow®’s bioactive compounds prevent platelet aggregation, by specific mechanisms not shared by lycopene. Lycopene is a fat-soluble antioxidant, which is responsible for the red colour of tomatoes. It is associated with some health benefits due to its antioxidant properties – mainly beneficial effects in prostate cancer – but has no effect on platelet aggregation. Fruitflow® does not contain any lycopene or other fat-soluble tomato compounds.

No, you cannot get the same effect by eating tomatoes. By taking the active ingredient out of the tomato it is absorbed into the body more quickly and effectively than if it was digested with the other solid parts of the tomato. This leads to an immediate benefit after taking Fruitflow®, which cannot be achieved by eating tomatoes.

It would be a good idea to take Fruitflow®+ Omega-3 at the same time each day to help ensure the benefits continue throughout the day, but if you forget, don’t worry, just take it when you remember.

Fruitflow® takes effect within three hours.

Blood platelets are not real cells, but fragments of other cells called megakaryocytes, which are produced in the bone marrow. Their main function is to ‘look after’ the circulatory system, by triggering blood clotting and repair of damaged tissue immediately after injury.
Platelets normally circulate in the blood as disc-shaped structures. In this form, they are called ‘smooth platelets’, and are inactive. If blood vessel walls are ruptured, for example when someone suffers a cut, molecules are released that trigger platelets in the area to change their shape (‘spiky’ platelets). Along with other molecules from the blood the platelets form a clot over the injury. Over time, this clot is reinforced to form a semi-permanent barrier behind which the injured tissue can mend. Once the tissue is repaired, the platelet plug slowly dissolves.

Blood platelets are not real cells, but fragments of other cells called megakaryocytes, which are produced in the bone marrow. Their main function is to ‘look after’ the circulatory system, by triggering blood clotting and repair of damaged tissue immediately after injury.
Platelets normally circulate in the blood as disc-shaped structures. In this form, they are called ‘smooth platelets’, and are inactive. If blood vessel walls are ruptured, for example when someone suffers a cut, molecules are released that trigger platelets in the area to change their shape (‘spiky’ platelets). Along with other molecules from the blood the platelets form a clot over the injury. Over time, this clot is reinforced to form a semi-permanent barrier behind which the injured tissue can mend. Once the tissue is repaired, the platelet plug slowly dissolves.