What is the evidence for a link between platelet aggregation and heart health?

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Giving antiplatelet drugs is a proven method of reducing risk of cardiovascular events and improving heart health, supported by a large number of trials from all around the world. Evidence also exists to show that antiplatelet drugs slow the development of fatty plaques in the blood vessels, which is one of the main causes of cardiovascular disease.

Platelets from some individuals at high risk of dying from a cardiovascular disease-related event – such as diabetics, or people who have had a previous stroke – are in a more activated or spiky state than those from low risk populations – such as people consuming a Mediterranean diet. Control of platelet function is known to be an effective therapy in these high-risk groups.